We recommend that faculty and staff use the Outlook Web App (opens a new window) to set their vacation / out of office message as it allows them to easily change automatic replies from home or the office.
Click on Options (top right corner), and select Set Automatic Replies... from the drop-down menu.
Select Send replies to all external senders, copy your vacation/out of office message from the first message box, and paste it in the second message box. (See image above text highlighted in red)